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医学论文

药物运输系统机制的研究进展

时间:2020年02月29日 所属分类:医学论文 点击次数:

幸运飞艇app【ZHAIYAO】SUIZHEXINCAILIAODECHANSHENG、XINDEZHIJIJISHUDECHUXIAN,XINGCHENGLEMAICHONGSHIJIYAOXITONG、HUANSHIHEKONGSHIJIYAOXITONG、JINGPIJIYAODEYAOWUCHUANSHUXITONG、BAXIANGJIYAOXITONGDENGSHIYAOXITONG,SHIYONGYAOGENGYOUXIAO、GENGANQUAN、GENGFANGBIAN。 【GUANJIANCI】YAOWUCHUANSHUXITONG;HUANSHIHEKONGSHIJIYAO;BAXIANGJIYAO;MAICHONGSHIJIYAOXITONG HUAGONGFANGXIANGLUN

  【ZHAIYAO】SUIZHEXINCAILIAODECHANSHENG、XINDEZHIJIJISHUDECHUXIAN,XINGCHENGLEMAICHONGSHIJIYAOXITONG、HUANSHIHEKONGSHIJIYAOXITONG、JINGPIJIYAODEYAOWUCHUANSHUXITONG、BAXIANGJIYAOXITONGDENGSHIYAOXITONG,SHIYONGYAOGENGYOUXIAO、GENGANQUAN、GENGFANGBIAN。

  【GUANJIANCI】YAOWUCHUANSHUXITONG;HUANSHIHEKONGSHIJIYAO;BAXIANGJIYAO;MAICHONGSHIJIYAOXITONG

药物运输

  化工方向论文投稿刊物:化工学报幸运飞艇app主要刊载过程科学与技术领域具有创造性的代表我国在这一方面基础与应用研究水平的学术论文;报道有价值的基础数据;扼要报道阶段性研究成果;接受读者来信,展开学术讨论;选载对学科发展起指导作用的综述与专论。

  YAOWUCHUANSHUXITONG(drugdeliverysystems,DDS)SHIZHIWEITIGAOLIAOXIAO,ZAIFANGZHIJIBINGDEGUOCHENGZHONG,RENMENCAIYONGDUOZHONGZHILIAOYAOWUDEBUYIYANGJIYUYAOWUDEFANGFA。MUQIAN,YIJINGYOUTONGLUOFEN、YINDUOMEIXIN、QINGDAMEISUDENGJIN3OZHONGKOUFUSHIFANGXITONG,XIAOHUAGANYOU、CIERCHUNDENGTOUPISHIFANGXITONG,DUOROUBIXING、ZISHANCHUNDENGZHIZHITI,GAOWANTONGYIBINGJIAOZHIYIJIAOZHIGONGJUWU(PLGA)WEIQIU,YIDAOSUYIJUBINGJIAOZHI(PLA)WEIQIU,ZHILIAOAIZHENGDEJIAANDIELINGMINGJIAOSHUANSAIWEIQIUDENGBAXIANGSHIFANGXITONGHUOZHUNJINRULINCHUANGYINGYONGll_。YAOWUCHUANSHUXITONGDEFAZHANDADAJIAKUAIBINGCHENGWEIXINYAOKAIFADEYIGEZHONGYAOTUJING。MUQIANYAOWUCHUANSHUXITONGFENLEIYOUYIXIAJIZHONG:

幸运飞艇app   1HUANSHI、KONGSHIJIYAOXITONG

  HUANSHIZHIJITONGCHANGSHIZHIWEILEDADAOYOUXIAODEZHILIAOXUEYAONONGDU,JINFUYAOWUHOUNENGZAISHENTINEIMANMANSHIFANGCHULAIBINGNENGBAOCHIXIANGDANGZHANGSHIJIANDEZHIJI。KONGSHIZHIJIXIZHISHIYAOSUDU,BUSHOUWAIJIETIAOJIANYINGXIANG,RUSUANJIANDU、CUIHUAMEI、WEICHANGYINSUDENG,JINSHOUJIYAOXITONGZIJIDEZHANGKONG。SHICHENGXUZHANGKONGSHIYAODEZHIJI。RUMAICHONGHUANSHIYAOWUDEWEIWAN、HENGDINGSHIFANGYAOWUDESHENTOUBENG、ZIZHUSHIFANGYAOWUDEYIDAOSUBENG、JIECHANGDINGWEISHIFANGYAOWUDERUANJIAONANGDENG,YIBANCAIYONGJIAONANGJI、HUNXUANJI、PIANJI。KONGZHISHIYAOMOSHIYOUSHENTOUBENGPIAN、SHUININGJIAOXING、WEIPIAOZHILIUXING、GUMOJIAXINGDENG。RUSHUANGLVFENSUANNAHUANSHIJIAONANG,TAKEBIMIANHUOJIANSHAOLEXUEYAONONGDUDE“GAOFENGDIGU”XIANXIANG,SHIXUEYAONONGDUDEWENDINGXINGZENGJIA。SHILIAOXIAOZENGJIA、DUFUZUOYONGJIANQING、YONGYAOCISHUJIANSHAO,SHIYICONGXINGTIGAO。

  2BAXIANGJIYAOXITONG

  BAXIANGZHIJIJIYAOHOUZUIXIANZHUTEDIANSHINENGZUIDAXIANDUJIANGZHILIAOYAOWUYUNZHUANDAOBAQU,QIBAQUNONGDUGAOCHUCHUANTONGZHIJISHUBEIDAOSHUBAIBEI,SHIZHILIAOXIAOGUOMINGXIANTISHENG。YUCITONGSHI,ZAIZHENGCHANGZUZHI,BAXIANGZHIJIDEFENBULIANGYUCHUANTONGZHIJIXIANGBIJIAOMINGXIANJIANSHAO。SHIYAOWUBULIANGFANYINGJIDUFUZUOYONGXIANZHUJIANQING,SHIZHILIAOXIAOGUODEDAOTISHENG,DADAOLIXIANGDEZHILIAOXIAOGUO13J。MUQIANBAXIANGZHIJIFENLEIYOURUXIAJIZHONG:

幸运飞艇app   2.1ZAITIDEXINGTAIHELEIXING

幸运飞艇app   KEFENWEIWEIQIUJI、HAOWEIQIUJI、ZHIZHITI、BAOHEWU、DANKELONGKANGTIOULIANWUDENGII。

  2.2BAXIANGYUANDONGLILEIXINGKEFENWEIBEIDONGBAXIANGZHIJI、ZHUDONGBAXIANGZHIJIHEWULIHUAXUEBAXIANGZHIJI。BEIDONGBAXIANGZHIJISHIZHIZAIYAOWEILI(ZHIZHITI、NAMILI、WEIQIU、RUJIDENG),BEIDANHEYIJUSHIXIBAOXITONGDEJUSHIXIBAO(TEBIESHIGANZANGDEKupfferXIBAO)SHEQU,XUANZEXINGDINONGJIYUTINEIWANGZHUANGNEIPIXITONG(RES)FENGFUDEZUZHI,QIGUAN(ZHUYAOSHIGANZANG、PIZANG)DEGUOCHENG。BEIDONGBAXIANGZHIJINENGLIYONGTONGTOUXINGZENGQIANGJIZHILIUXIAOYINGSHENCHUBINGDINGWEIYUZUZHIJIANXINEI,LIRUZHONGLIUXIBAOHUIZIJISHIFANGCHUXIBAOYINZIHEQITAXINHAOFENZI,YINWEIZHONGLIUXIBAONENGCHAJUEYINGYANGHEYANGQIBUNENGMANZUSHENGZHANGXUYAO,ZHEIYANGKEYICUSHIZAIZHONGLIUFASHENGCHUSHENGZHANGCHUXINDEXUEGUAN。DADUOSHUZHENGCHANGZUZHIZHONGDEXUEGUANNEIPIXIBAOFEICHANGJINMI,XINSHENGXUEGUANNEIPIXIBAOMEIYOUNEIMEJINMI,QIELINBAPAIXIENENGLIMEIYOUNEIMEQIANG,ZAIZHONGLIUZUZHI,ZAITIQINGYINENGGOUDALIANGJUJI,YUZAIZHENGCHANGZUZHIXIANGBI,KEYIZENGJIAZHI10BEINONGDU【5I。

幸运飞艇app   ZHUDONGBAXIANGZHIJIGENGGAOJI.KEYIDAODAYOULIYAOWUWUFADAODADEBUWEI。LIYONGQIANHETAIJISHUZHIBEIDEJIEDAOXINGZAITIDEYAOWUCHUANSHUXITONG,XUENAOPINGZHANGTONGGUOLVSHIHENGAODE。ZAICIXITONGZHONG,YAOWUTONGGUOQINHESUYIHUAXUEJIANYISHENGWUSUJISHU、ZHIZHITIYUJINGGUOXIUSHIDEDANBAIZHIHUOTEYIXINGSHOUTIDEDANKELONGKANGTIDEZAITILIANJIEQILAI,TONGGUOBAOTUN、ZHUANYUNZUOYONG,ZAISHOUTIDEZHONGJIECHUANDAOXIAJINRUDANAO,SHIHUANZHEDEDAOGENGHAODELIAOXIAOCHAO。XIANZAIJIAOXINDEZHUDONGBAXIANGXINGZHIJIZHUYAOYOUJIANGDANKELONGKANGTIYUYESUANZHIZHITIXIANGLIANJIE、JIANGTANGDANBAIZAITIYUDANKELONGKANGTILIANJIE、JIANGBIAOMIANHANYAODEZHIZHITIYUDANKELONGKANGTILIANJIEDENGSHOUTIXINGBAXIANGZHIJI。MIANYIZHIZHITIKEYIHUIBIJUSHIXIBAODETUNSHI。WULIHUAXUEBAXIANGZHIJISHIYONGYIXIEHUAXUEWULIFANGFA.ZAITEDINGBUWEISHIBAXIANGZHIJIFAHUICHUZUOYONG。LIRUYONGZAITIDUIWENDUMINGANDE,YONGTAZHICHENGREMINZHIJI,ZAIWENDUDEZUOYONGXIA.ZAIBAQUNEISHIREMINZHIJISHIFANGYAOWU;YEKECAIYONGpHMINGANDECAILIAOZHICHENGpHMINGANZHIJI,SHIYAOWUZAITEDINGpHBAQUNEISHIFANGYAOWU。

  3MAICHONGSHIJIYAOXITONG

  MAICHONGSHIJIYAOXITONGSHIGENJUDINGSHIKONGZHIBENGJIEJIZHISHEJIDE,NENGZAIBUTONGSHIJIANFAHUILIAOXIAO,SHILIAOXIAOTIGAO,NAISHOUNENGLIJIAQIANG,DADAOZUIHAOLIAOXIAO。CIXITONGZAIYUSHEDESHIJIANDANCIHUODUOCISHIFANGYAOWU.ZAIZHEIGESHIJIANDUANZHILIAOHUANZHE,TABINGBUSHIYAOWEICHIWENDINGDEXUEYAONONGDU。TADEZHIJIELJISHIYOULAZHIJIAJUYIERCHUN(PEU)ZUOCHENG,GAOXIAOBENGJIEJIHEYAOWUZUCHENGPIANRUI,YIBANYOURONGSHIXING、PENGZHANGXINGHESHENTOUXINGYICENG,KEBAOZAIPIANRUIDEWAICENG,YONGLAIZHILIAOMOUXIETEDINGSHIJIANDUANFABINGDEHUANZHE。RUXIAOCHUANCHANGZAIBANYEFAZUO,SHIYONGLIUSUANSHADINGANCHUNMAICHONGPIANZHILIAO,TIWAISHIYAOXIAOGUOBIAOMING,ZHUYAOMAICHONGSHIYAOZAI200minSHI,DADAOYOUXIAOXUEYAONONGDUDESHIJIANSHI4~5h。

  MUQIANYANZHIDECHAJIAN2CIMAICHONGSHIYAOWEIWAN,ZI45minNEI,DIYICIMAICHONGSHIFANGYAOWU。ZAI3.5hNEI,DIERCIMAICHONGSHIFANGYAOWU,JINGGUO3hDAODAYOUXIAOZHILIAONONGDU。HUANZHEWAN10:00FUYAO,DUIYEJIANXIAOCHUANYUFANGFAZUO、ZHILIAOYOUHENHAOLIAOXIAO。SHIHUANZHETONGKUJIANSHAO[7~81。4JINGPIJIYAODEYAOWUCHUANSHUXITONGJINGPIJIYAOXITONG(transdermaldrugdeliverysystems,TDDS)SHIYAOWUTONGGUOPIFUXISHOUJINRENRENTIXUEYEXUNHUANBINGDADAOYOUXIAOXUEYAONONGDU,SHIXIANJIBINGZHILIAOHUOYUFANGDEYILEIZHIJI。ZHEILEIZHIJIZAIOUMEIGUOJIAXICHENGTIEJI(patch),ZAIGUONEIDUODINGMINGWEITIEPIAN。TADEYOUDIANSHIBUTONGGUOKOUFUYAOWU。MEIYOUGANCHANGDAIXIEDEYAOWUSUNSHI,XUEYAONONGDUWENDING,YAOLIXIAOYINGWEICHI,JIYAOCISHUJIANSHAO,KEYOUXIAOYANZHANGZUOYONGSHIJIAN,FANGBIANHUANZHESHIYONG,SHIYICONGXINGTIGAO。LIRU,XIAOSUANGANYOU1:3FUJIYAO,90%BEIGANZANGPOHUAI,SHEXIAJIYAO.WEICHISHIJIANHENDUAN。ERXIAOSUANGANYOUTI)DSKEWEICHI24hYOUXIAONONGDU。

  FENTAINIZHANGXIAOTIEPIANDUIZHONGLIUDENGHUANZHEJUYOULIANGHAOZUOYONG,TAZUOYONGSHIJIANZHANGDA72h,NENGWEICHIXUEYAONONGDUWENDING.ZHENTONGXIAOGUOMINGXIANDEDAOTISHENG,BULIANGFANYINGDEFASHENGXIAJIANG。TDDSMUQIANYOUJIZHONGXINJISHUDEFAZHAN,RUJIGUANGDAORUJISHU、DIANZHIKONGDAORUJISHU、CHAOSHENGBODAORUJISHU、SHENGWUZHUJITIJISHU、CIDAORUJISHUDENG19]。5ZHONGYAOZHIJIYANJIUJINZHANZHONGYAOZHIJISHIWOGUOYAOJIXUECHUANTONGDEZHONGYAOZUCHENGBUFEN,ZHONGYAOBAXIANGJISHUYANJIUQUDEHENDAJINZHAN,RUZHONGYAOWEIRUBAXIANGJISHU、KOUFUYETIWEIRUZHIJI、JINGPIJIYAOWEIRUZHIJI、NIANMOJIYAOWEIRUZHIJI、ZHUSHEYONGWEIRUZHIJI、ZHONGYAOWEIQIUBAXIANGJISHU、ZHONGYAONAMILIBAXIANGZHIJIDENG。ZHANGNINGDENG㈣CAIYONGCHAOSHENG、GAOYAYUNZHIFAZHIBEILEJINGZHUYONGDANCANTONGWEIRU。ZHANGLIDENG…1ZHIBEILEQUJIABANMAOSU(NCTD)DEWEIRUZHUSHEYE,SHIGANZANGZHONGLIUXIBAOBEIYIZHILE。

  YUJIADENG【21ZHICHENGLEQIAOJUTANGHEJUYIXIBIGEWANTONGDESHUININGJIAOYINXINGNAMILI。ZHEIZHONGNAMILIJINGMAIZHUSHEHOU,YINWEINAMILIBIAOMIANJUYOUQINSHUIXING,SUOYIJUSHIXIBAONANYISHIBIETUNSHI,NAMILIKEYIDAODABAZUZHIYUBAXIBAOJIEHE,TIGAOBAZUZHIZHONGYAOWUCHENJILIANG,DADAOGENGHAODELIAOXIAO。JINGGUOJISHINIANDEFAZHAN。YAOWUCHUANSHUXITONGDEYANJIUHEKAIFAYIJINGJILEILEXIANGDANGDUODELILUNHEJISHUJICHU。SUIZHEGONGNENGJIYINZUXUE、DANBAIZHIXUE、DAIXIEZUXUE、BINGLIXUE、FENZIYAOLIXUE、XITONGGONGCHENGXUE、GANXIBAOJISHU、NAMIJISHU、WEIJIAGONGJISHUDENGJIAOHUSHENTOU,CUJINFAZHAN,JIANGHUIYOUYUELAIYUEDUOGAOXIAO、ANQUAN、FANGBIAN、SHIYONGDEYAOWUCHUANSHUXITONGXINCHANPINYANFACHULAI。

  【CANKAOWENXIAN】

幸运飞艇app   [1】LIUXIUDONG,MAXIAOJUN,YUANQUAN.YAOWUSHIFANGXITONGTAO.HUAGONGXUEBAO,2005,56(6):955-956.

幸运飞艇app   [2】LangerR.DrugDeliveryandTargetirte[J].Nature,1998,393(6684):66—79.

  [3】Nagaichs,KhopadeAJ,JainNK.LipoGraftsofEgg-boxComplex,aNewSupramolecularBiovectorfor5-fluorouracilDelivery[J].PharmActaHelv,1999,73(5):227-229.