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农业论文

中链脂肪酸在仔猪营养中的生理功能研究进展

时间:2020年03月23日 所属分类:农业论文 点击次数:

ZHAIYAO:ZHONGLIANZHIFANGSUAN(MCFAs)YOUHANYOUDANSUOSUANDEZHIFANGSUANZUCHENG,6~12GETANYUANZIBUDENG,BAOKUOJISUAN(C6)、XINSUAN(C8)、GUISUAN(C10)HEYUEGUISUAN(C12)。MCFAsKEYITONGGUOWEINIANMOBEIXISHOU,ZHONGLIANZHIFANGSUANGANYOUSANZHI(MCTs)KEYIBEIWANZHENGDIXISHOUJINRUCHANGSHANGPIXIBAO,RANHOUBEIWEILITIZHIFANGMEISHUIJIE。MCFAsSHIYIZHONGHENRONGYI

幸运飞艇app   ZHAIYAO:ZHONGLIANZHIFANGSUAN(MCFAs)YOUHANYOUDANSUOSUANDEZHIFANGSUANZUCHENG,6~12GETANYUANZIBUDENG,BAOKUOJISUAN(C6)、XINSUAN(C8)、GUISUAN(C10)HEYUEGUISUAN(C12)‍‌‍‍‌‍‌‍‍‍‌‍‍‌‍‍‍‌‍‍‌‍‍‍‌‍‍‍‍‌‍‌‍‌‍‌‍‍‌‍‍‍‍‍‍‍‍‍‌‍‍‌‍‍‌‍‌‍‌‍。MCFAsKEYITONGGUOWEINIANMOBEIXISHOU,ZHONGLIANZHIFANGSUANGANYOUSANZHI(MCTs)KEYIBEIWANZHENGDIXISHOUJINRUCHANGSHANGPIXIBAO,RANHOUBEIWEILITIZHIFANGMEISHUIJIE‍‌‍‍‌‍‌‍‍‍‌‍‍‌‍‍‍‌‍‍‌‍‍‍‌‍‍‍‍‌‍‌‍‌‍‌‍‍‌‍‍‍‍‍‍‍‍‍‌‍‍‌‍‍‌‍‌‍‌‍。MCFAsSHIYIZHONGHENRONGYIHUODEDENENGLIANGLAIYUAN,BUJINNENGGOUGAISHANCHANGSHANGPINIANMOJIEGOU,HAIYINQINENGGOUCHUANTOUXIJUNDEBANTOUMOBINGPOHUAIXIBAONEIBUJIEGOUERJUYOUHENQIANGDEKANGJUNHUOXING‍‌‍‍‌‍‌‍‍‍‌‍‍‌‍‍‍‌‍‍‌‍‍‍‌‍‍‍‍‌‍‌‍‌‍‌‍‍‌‍‍‍‍‍‍‍‍‍‌‍‍‌‍‍‌‍‌‍‌‍。YINCI,MCFAsKEYIZUOWEIDUANNAIZIZHUSILIAODELIANGHAOBUCHONGJI,TIGAOZIZHUDESHENGZHANGXINGNENG,SHIYIZHONGQIANZAIDESILIAOKANGSHENGSUTIDAIPIN。BENWENJIANGCONGMCFAsDUIZIZHUSHENGZHANGXINGNENG、CHANGDAOWEISHENGWUPINGHENG、CHANGDAOFAYUJIMIANYIDIAOJIEZUOYONGJINXINGZONGSHU,WEIMCFAsZAIYANGZHUYEZHONGDEKEXUEYINGYONGTIGONGCANKAO。

幸运飞艇app   GUANJIANCI:MCFAs;SHENGZHANGXINGNENG;YIJUN;ZIZHU

动物饲养

  畜牧方向论文范文:动物易感染疾病在畜牧养殖中的类型和防治

  【ZHAIYAO】SUIZHEWOGUOJINGJIDEFAZHAN,CHUMUYANGZHIYEXIANJIEDUANYIJINGCHENGWEILEWOGUODEYIXIANGZHONGYAOCHANYE;GEDICHUMUYANGZHIYEDEYANGZHIGUIMOYUYANGZHIDONGWUDEZHONGLEIDOUDEDAOLEKUOZHANG,BUDANTIGAOLECHUMUYANGZHIYEDEJINGJISHOUYI,TONGSHIYEMANZULESHEHUISHANGDUIYUGEZHONGDONGWULESHIPINDEXUQIU。DANZAICHUMUYANGZHIDEGUOCHENGZHONG,SHOUDAOSHEHUIGUANZHUZUIWEIGUANGFANDEBIANSHIDONGWUJIBINGDEFANGKONGWENTI。BENWENZHEZHONGDUICHUMUYANGZHIDEDONGWUGANRANJIBINGBINGYINYUFANGKONGDUICEZHANKAILESHENRUDEFENXIYUTANTAO。

幸运飞艇app   SUIZHEOUMENGJINZHIZAINONGCHANGDONGWUSIYANGZHONGSHIYONGKANGSHENGSUSHENGZHANGCUJINJIYILAI,KANGSHENGSUZAISHIJIEFANWEINEIMANMANJINYONGHUOXIANYONG,KANGSHENGSUTIDAIPINJICHENGWEIDONGWUYINGYANGLINGYUDEYANJIUREDIANZHIYI,GEZHONGYUFANGZIZHUWEICHANGJIBINGDEKANGSHENGSUTIDAIPINYIBEITICHU[1]。ZHONGLIANZHIFANGSUAN(Medium-ChainFattyAcids,MCFAs)NENGGOUCHUANTOUXIJUNDEBANTOUMOBINGPOHUAIQINEIBUJIEGOU,JUYOUHENQIANGDEKANGJUNHUOXING[2],HAINENGGOUWEICHICHANGSHANGPINIANMOJIEGOU,GAISHANDUANNAIZIZHUCHANGDAOFAYU[3],SHIYIZHONGQIANZAIDEKANGSHENGSUTIDAIPIN。BENWENZONGSHULEMCFAsDUIZIZHUSHENGZHANGXINGNENGDEYINGXIANG,BINGZAICIJICHUSHANGTICHUMCFAsYINGXIANGSHENGZHANGXINGNENGDEKENENGYINSUJIJIZHI,ZHIZAIWEISHENRURENSHIMCFAsGONGNENGJIJINYIBUJIESHIQIDUIZIZHUSHENGZHANGXINGNENGDEYINGXIANGJIZHITIGONGCANKAO。

  1MCFAsDELAIYUAN、DAIXIEJIYINGYONG

  MCFAsYOUHANYOUDANSUOSUANDEZHIFANGSUANZUCHENG,TANLIANZHANGDUZAI6~12,BAOKUOJISUAN(C6)、XINSUAN(C8)、GUISUAN(C10)HEYUEGUISUAN(C12)DENG[4]。MCFAsYUGANYOUFASHENGZHIHUAFANYINGHOUKESHENGCHENGXIANGYINGDEZHONGLIANZHIFANGSUANGANYOUSANZHI(MCTs)。MCTsCUNZAIYUDONGWUDERUZHIJIDUOZHONGSILIAOYUANLIAOZHONG,QIZHONGYEZIYOU、ZONGLVYOUJIEJUHUAZHONGZIYOUZHONGHANLIANGJIAOWEIFENGFU[5]。

幸运飞艇app   XIANGDUIYUZHANGLIANZHIFANGSUAN(LCFAs)LAISHUO,MCFAsSHIDONGWUKUAISUDEGONGNENGWUZHI,ZAIDONGWUSHENGZHANG、FANZHI、MIANYI、ZHIFANGCHENJIJICHANGDAOJUNQUNDENGFANGMIANYOUZHEZHONGYAODEZUOYONG[6]。MCFAsFENZILIANGXIANGDUIJIAOXIAO,RUHUANENGLIQIANG,SHUIJIENENGLISHILCFAsDE6BEI,TONGSHIHAIKEYICUJINLCFAsDERUHUA[7]。YANJIUFAXIAN,ZAIMEIYOUYIMEICANYUDEQINGKUANGXIA,MCFAsYEKEDADAOZHENGCHANGXISHOUSHUIPINGDE50%ZUOYOU,SHUOMINGMCFAsSHUIJIEDUIYIMEIDEYILAIXINGDI[8]。CHUSHENGZIZHUDECHANGDAOJIXIAOHUAXITONGFAYUBUGOUWANSHAN,QUEFADANYANHUOYIZHIMEI。

幸运飞艇app   MCTsKEYIZHIJIEXISHOUJINRUZIZHUXIAOCHANGSHANGPIXIBAONEIJINGGUOZHIFANGMEIWANQUANSHUIJIECHENGMCFAsHEGANYOU,YINCIMCTs/MCFAsNENGGOUBEICHUSHENGZIZHUYOUXIAODIXIAOHUA、XISHOUHELIYONG,XUNSUGAISHANTINEINENGLIANGZHUANGKUANG[9-10]。JIDASHUSIWEIFANGSHEXINGBIAOJIDEMCFAsHOU,BINGMEIYOUZAILINBAGUANNEIFAXIANMCFAsDECUNZAI,SHUOMINGMCFAsBUJINGGUOLINBAXITONGERZHIJIEYOUGANMENJINGMAIRUGAN[11]。MCFAsYUDANBAIZHIJIEHELIDI,ZHIJIEYOUYIZHIFANGMEIXUNSUSHUIJIEHOUJINRUXIAOCHANGSHANGPIXIBAO,BEIKUAISUXISHOUHOUZAIXIBAONEIBUZAIHECHENGGANYOUSANZHI,ERSHITONGGUOMENJINGMAIZHIJIESONGDAOGANZANG,ZAITINEIKUAISUBEIQINGCHUBINGZHIJIEZAIGANZANGDAIXIEWEINENGYUAN[12-14]。

  ZI19SHIJI50NIANDAIKAISHI,MCFAsYINGYONGYURENLEIZHIFANGXISHOUBULIANGZHENGERJINJUNYIYAOXINGYE,DUIZHILIAOFEIPANG、YIDAOSUDIKANG、WEICHANGYANHEXINNAOXUEGUANJIBINGJUYOUZHONGYAODEZUOYONG[15]。YOUYUMCFAsHAIYOURUHUAHEKANGWEISHENGWUDEZUOYONG,YINERGUANGFANYINGYONGYUSHIPINHEHUAZHUANGPINXINGYE[15]。WOGUOZAI1986NIANJIANGXINKUISUANGANYOUSANZHILIERUGUOBIAOBINGZAI1996NIANBEIWEISHENGBUPIZHUNKEYONGZUOSHIPINTIANJIAJI。MCFAsDEZHUYAOZUOYONGSHIKUAISUGONGNENG,KEZUOWEIXINSHENGYOUZAIDENENGLIANGBUCHONGJI,TEBIESHIZAIZAOCHANYINGERFANGMIANDEYINGYONG,ZI20SHIJI80NIANDAI,MCFAsKAISHIYINGYONGYUXINSHENGZIZHUZHONG,WEIZIZHUCHUSHENGZHIDUANNAIQIANHOUJIEDUANTIGONGZUGOUDENENGYUANLAIDIYULAIZIGEFANGMIANDEYINGJI,MANZUZISHENSHENGZHANGFAYUDEXUYAO[16-17]。ZI2006NIANOUMENGQUANMIANJINKANGYILAI,ZAIQUANQIUYANGZHIYEYANGEKONGZHISHIYONGKANGSHENGSUJIQITAHUAXUEYAOPINFANGZHIYAOWUCANLIU、XUNZHAOKANGSHENGSUTIDAIPINDEDAHUANJINGXIA,MCFAsZUOWEIYIZHONGXINXINGTIANJIAJIZAISILIAOXINGYELINGYUZHONGDEYINGYONGYINQILEGUANGFANGUANZHU[18]。

幸运飞艇app   2MCFAsDESHENGLIDIAOJIEZUOYONG

  MCFAsSHIYIZHONGHENRONGYIHUODEDENENGLIANGLAIYUAN,BUJINKEYIWEIZIZHUTIGONGKUAISUYOUXIAODENENGLIANG,GAISHANCHANGSHANGPINIANMOJIEGOU,TIGAOSHENGZHANGXINGNENG,HAIJUYOUHENQIANGDEKANGJUNHUOXING,KEYIDIAOJIEZIZHUXIAOHUADAOWEISHENGWUZUCHENG,ZENGQIANGZIZHUMIANYILI。YINCI,MCFAsDUIZIZHUSHENGLIJUYOUDIAOJIEHEKONGZHIZUOYONG。

幸运飞艇app   2.1MCFAsDUIZIZHUSHENGZHANGXINGNENGDEYINGXIANG

  MCFAsDUIZIZHUSHENGZHANGXINGNENGYINGXIANGDEYANJIUJIEGUOBUJINYIZHI。ZHANGHAODENG[19]YONGBUTONGJIXINGMCTs(YETAIHEGUTAI,TIANJIALIANG1.4%)TIDAIDUANNAIZIZHUSILIANGZHONGDEDADOUYOU,JIEGUOFAXIAN2ZHONGJIXINGDEMCTsJUNKETIGAOZIZHUDUANNAIHOU2ZHOUXUEYEZHONGZONGDANBAIHANLIANG;GUTIMCTsXIANZHUTIGAOZIZHUDUANNAIHOU2ZHOUPINGJUNRIZENGZHONGHEXUEYEZHONGD-MUTANGHANLIANG,JIANGDIXUEYEZHONGNIAOSUDANHANLIANG,SHUOMINGMCTsKECUJINDUANNAIZIZHUCHANGDAOXISHOUNENGLIDEHUIFU,GAISHANDANBAIZHIDAIXIE,JINERCUJINSHENGZHANG,QIZHONGYIGUTIMCTsXIAOGUOGENGHAO。HanczakowskDENG[20]YANJIUZHICHU,DUANNAIZIZHUSILIANGZHONGTIANJIAMCFAs(0.3%GUISUANHUO0.3%XINSUAN)KETIGAODUANNAIHOU0~28dDEPINGJUNRIZENGZHONG,GAISHANSHENGZHANGXINGNENG。MCFAs/MCTsKECIJICHANGCUYIMEITAIDEFENMI,ERCHANGCUYIMEITAIKECUJINYIDANBAIMEI、ZHIFANGMEIDENGXIAOHUAMEIHUOXINGDETIGAO,JINERTIGAOYANGFENXIAOHUALV,TIGAOZIZHUSHENGZHANGXINGNENG[21]。

  MCTs(0、0.7%、1.4%、2.1%)TIDAIDADOUYOUKETIGAODUANNAIHOU2ZHOUHEQUANQIDESILIAOZHUANHUALV,TONGSHI,ZHONGDENGJILIANGTIDAI(0.7%HE1.4%)KEXIANZHUGAISHANZIZHUDUANNAIHOU12~14dCUZHIFANGHEGANWUZHIDEBIAOGUANXIAOHUALV,ZENGJIAXUEQINGZHONGZONGDANBAIHANLIANG,JIANGDINIAOSUDANSHUIPING,SHUOMINGMTCsNENGGAISHANYANGFENLIYONGLV,JINERTIGAODUANNAIZIZHUSHENGZHANGXINGNENG,ZHEIKENENGYUXIAOHUAMEIHUOXINGDEZENGJIAYOUGUAN[22]。DeviDENG[23]HETANGWENJIEDENG[24]YEDEDAOLEXIANGSIJIEGUO。ZAISHANGYETIAOJIANXIA,RILIANGBUCHONGYOUJISUANHEMCFAsHUNHEWU(JIASUANGAI、RUSUANGAI、NINGMENGSUANHEMCFAs,0.3%)XIANGBIYUYANGHUAXIN(ZnO)GENGJIAYOULIYUDUANNAIZIZHUDESHENGZHANG,SHUOMINGMCFAsYUSUANHUAJILIANHESHIYONGJUYOUXIETONGCUSHENGZHANGDEZUOYONG,KETIDAIYANGHUAXINZAIZIZHUSHANGDESHIYONG[25]。

幸运飞艇app   LanDENG[26]ZAIBURUZIZHUSHANGDEYANJIUDEDAOLEXIANGSIJIEGUO,MUZHUSILIANGZHONGTONGSHITIANJIAMCFAsHEYOUJISUANKETIGAOHOUDAIZIZHUSHENGZHANGXINGNENG。DANCHENCHEN[27]YANJIUBIAOMING,SILIANGTIANJIA0.2%、0.4%HUO0.6%DEMCFAsDUIDUANNAIZIZHUDESHENGZHANGXINGNENGWUXIANZHUYINGXIANG,DANJIANGDILEDUANNAIZIZHUWEIHECHANGDAOQIANDUANDEpH,QIDAOSUANHUAJIDEZUOYONG,KETIGAOXIAOCHANGRONGMAOGAODU,CUJINYINGYANGWUZHIXIAOHUAXISHOU,QIZHONGYI0.2%DETIANJIASHUIPINGXIAOGUOZUIHAO。CHENSHAOKUI[28]TONGYANGFAXIAN,4%DEMCFAsDUIZIZHUSHENGZHANGXINGNENGWUXIANZHUYINGXIANG,DANXIANZHUGAIBIANCHANGDAOHEGANZANGZHIFANGSUANZUCHENGFASHENG,ZENGJIAKONGCHANGZHETANGMEIHEMAIYATANGMEIYIJIHUICHANGJIANXINGLINSUANMEIHUOXING,GAISHANXIAOHUAXISHOUGONGNENG。SUIRANMCFAsDUISHENGZHANGXINGNENGDEYANJIUJIEGUOBUYIZHI,DANQIJUNKETIGAOYANGFENXIAOHUALVJIXIAOHUAMEIHUOXING,ERBUYIZHIDEYUANYINKENENGYUMCFAsDETIANJIAXINGSHI、TIANJIALIANG、SHENGCHANGONGYI、RILIANGZHONGQITAYINGYANGSUDESHUIPINGJIHUANJINGYINSUYOUGUAN。

  GUANYUMCFAsDUIZIZHUSHENGZHANGXINGNENGDEYINGXIANGHAIKENENGYUWEIJIESU(Ghrelin)DEFENMIYOUGUAN[29]。GhrelinDEZHUYAOHUOXINGXINGSHISHIYIZHONGYOU28GEANJISUANGOUCHENGDETAI,JUYOUCUJINSHENGZHANGJISU(GH)SHIFANG、DIAOJIEDONGWUCAISHIJINENGLIANGPINGHENGDENGGONGNENG。GHDEZHUYAOSHENGLIGONGNENGSHICUJINJITIDANBAIZHIHECHENGHEZUZHISHENGZHANG,ZENGQIANGJITIDUIKUANGWUYUANSURUGAI、LIN、JIA、LIUDENGDESHEQU,JIASUZHIFANGFENJIE,YINGXIANGDANBAIZHIHENENGLIANGDAIXIE[30]。YANJIUBIAOMING,JINSHILCFAsKEJIANGDIRENXUEJIANGZHONGZONGGhrelinSHUIPING,ERJINSHIMCFAs(XINSUANC8:0)HUOMCTs(XINSUANGANYOUZHI)KEZHIJIEYONGYUGhrelinDEXIANHUA,XIANHUAHOUDEGhrelinKECUJINGHDEFENMI,CIJIDONGWUCAISHIJIWEISUANFENMI,CONGERDUIDONGWUSHENGZHANGXINGNENGCHANSHENGJIJIDEYINGXIANG[29]。

  MillerDENG[31]YANJIUFAXIAN,RILIANGZHONGTIANJIA5%MCTsZENGJIALEDUANNAIZIZHUXUEJIANGZHONGGHHEGhrelinDENONGDU,JIANSHAOZIZHUFUXIELV,WEICHILEQIXIAOCHANGRONGMAOGAODUJINERTIGAOZIZHURIZENGZHONG。GhrelinDEDI3GEANJISUAN(SIANSUAN)SHANGHANYOUXINSUAN(C8:0)ZHIFANGSUAN,ERMCTsJUYOUGAONONGDUXINSUAN,SHUOMINGRILIANGZHONGTIANJIAMCTsZUOWEIYIZHONGWEIJITITIGONGHUOHUAGhrelinDEFANGSHI,TONGGUOCIJIGHNEIFENMITUJINGJIANGDUANNAIXIANGGUANBINGZHENG(LIRUSHENGZHANGCHIHUANHEFUXIE)JIANGDAOZUIDI,BINGJIANSHAOLEDUANNAIHOUGHSHUIPINGDEXIAJIANG,CUJINSHENGZHANG[31]。

  2.2MCFAsDUIWEICHANGDAOWEISHENGWUDEDIAOJIE

幸运飞艇app   MCFAsSHIYIZHONGYINLIZIDEBIAOMIANHUOXINGJI,KEPOHUAIXIJUNMO,JINRUXIJUNXIBAONEI,YIZHIBAONEIZHIFANGMEIDEHUOXING,CONGERFAHUIKANGJUNZUOYONG[32]。TIWAIYANJIUFAXIAN,SUIZHEpHDESHENGGAO,MCFAsDEYIJUNXIAOGUOXIAJIANG[33]。ZAIpHWEI3HE5SHI,JISUANHEXINSUANCHULIZUDEDACHANGGANJUNJUNWUSHENGZHANG,DANZAIpHWEI5SHI,GUISUANCHULIZUDACHANGGANJUNCHUXIANLESHENGZHANG[34],SHUOMINGMCFAsDEYIJUNXIAOGUOSHOUJITIWEICHANGDAODEpHYINGXIANG。QIJIAOJIAODENG[35]YANJIUBIAOMING,JISUAN、XINSUAN、GUISUANDUIDACHANGGANJUN、SHAMENSHIJUNHEJINHUANGSEPUTAOQIUJUN3ZHONGZHISHIJUNJUNJUYOUJIAOQIANGDEYIZHIZUOYONG,QIEMCFAsYUROUGUIQUANLIANHESHIYONGJUYOUXIETONGHUOXIANGJIAZUOYONG。XINSUANHEGUISUANDUIGELANSHIYANGXINGJUNDEYIZHIZUOYONGJIAOGELANSHIYINXINGJUNQIANG,YUEGUISUANZHUYAOYIZHIGELANSHIYINXINGJUN[36],XINSUANHEGUISUANTONGSHISHIYONGJUYOUXIETONGYIJUNXIAOYING[37]。TONGYANGZUOWEIGELANSHIYINXINGJUN,SHAMENSHIJUNBIDACHANGGANJUNDUIMCFAsGENGMINGAN[38]。KEJIAN,MCFAsDEYIJUNXIAOGUOHAIYUQILIANZHANGMIQIEXIANGGUAN。

  ZIZHUSHANGDEYANJIUFAXIAN,RILIANGTIANJIAMCTs(0.5%、1.0%HE1.5%)XIANZHUJIANGDIKONGCHANG、HUICHANGHEJIECHANGLIANQIUJUNDEBILI,SUIZHERILIANGZHONGMCTsTIANJIALIANGDEZENGJIA,GECHANGDUANRUSUANGANJUN、SHUANGQIGANJUNZHANZONGXIJUNDEBILITIGAO,DACHANGGANJUNBILIJIANGDI[24],DANGMCTsTIANJIALIANGDADAO3%SHI,ZIZHUJIECHANGHEZHICHANGSUOJUNDESHULIANGXIANZHUJIANGDI[39];SILIANGTIANJIAMCFAs(0.2%、0.4%HE0.6%)JIANGDIKONGCHANGDACHANGGANJUNHESHAMENSHIJUNDESHULIANG,ZENGJIASHUANGQIGANJUNHERUSUANGANJUNDESHULIANG[27]‍‌‍‍‌‍‌‍‍‍‌‍‍‌‍‍‍‌‍‍‌‍‍‍‌‍‍‍‍‌‍‌‍‌‍‌‍‍‌‍‍‍‍‍‍‍‍‍‌‍‍‌‍‍‌‍‌‍‌‍。YANGJINTANG[40]HEHanczakowskaDENG[20]DEDAOLELEISIJIEGUO,RILIANGTIANJIA0.3%DEMCFAsTIGAOZIZHUFENBIANZHONGRUGANJUNSHULIANG,JIANGDIZIZHUFENBIANZHONGDACHANGGANJUN、SHAMENSHIJUNHECHANGQIUJUNSHULIANG。

  YISHANGYANJIUJUNZHENGSHI,MCFAsDUICHANGDAOWEISHENGWUJUNQUNQIZHEDIAOJIEHEGAISHANZUOYONG,YIZHIYOUHAIJUNZENGZHIDETONGSHITIGAOYOUYIJUNSHULIANG,WEICHICHANGDAOWEISHENGWUJUNQUNJIANDEPINGHENG。MCFAsYUYOUJISUANZAIZIZHUTINEILIANHESHIYONGJUYOUXIETONGDIAOJIECHANGDAOJUNQUNDEZUOYONG。ZentekDENG[41]BIJIAOYOUJISUAN(0.416%FUMASUANHE0.328%RUSUAN)HE/HUOMCFAs(0.15%XINSUANHE0.15%GUISUAN)DUIDUANNAIZIZHUCHANGDAOWEISHENGTAIYINGXIANGDEYANJIUZHONGFAXIAN,SILIANGTIANJIA0.15%MCFAsXIANZHUJIANGDIWEI、KONGCHANGHEHUICHANGSHIMIpH,ZENGJIAKONGCHANGSHIMIEscherichia-Hafnia-ShigellaHEJIECHANGSHIMIClostridialclusterXIVaDESHULIANG,QIEYOUJISUANHEMCFAsTONGSHITIANJIAXIAOGUOGENGHAO。HanDENG[42]YANJIUYEBIAOMING,SILIANGTONGSHITIANJIA0.2%YOUJISUANHE0.6%MCFAsZENGJIADUANNAIZIZHUCHANGDAOSHIMIZHONGHOUBIJUNMEN、BIANXINGJUNMEN、RUSUANGANJUNSHUHEFENGANJUNSHUDESHULIANG。JIYUYISHANGJIEGUOKEZHI,MCFAsHEYOUJISUANLIANHESHIYONGKEJIANGDICHANGDAOSHIMIpH,TIGAOCHANGDAOYOUYIJUNDESHULIANG,JINERDIAOKONGCHANGDAOWEISHENGWUDEZUCHENG,YOUXIAOYUFANGDUANNAIZIZHUFUXIE。

  2.3MCFAsDUIZIZHUMIANYIGONGNENGDEDIAOJIE

幸运飞艇app   XIBAOMOZHONGBAOHEZHIFANGSUANHANLIANGDEZENGJIAHUIJIANGDIXIBAOMODELIUDONGXING,JINERYINGXIANGMIANYIXIBAODETUNSHINENGLI,YINCI,MCFAsZUOWEIBAOHEZHIFANGSUANCANYUJITIMIANYIGONGNENGDEDIAOKONG[43]。TIWAIYANJIUBIAOMING,XINSUANJIGANYOUYIZHIYIZHILECaco-2XIBAOBAIJIESU8(IL-8)DEFENMI,ERGUISUANQUEZENGQIANGLEIL-8CHANLIANG[44],SHUOMINGMCFAsCANYUDEMIANYIDIAOJIEYUQIZHONGLEIYOUGUAN。TINEISHIYANFAXIAN,JINSHIMCTsCUJINDACHANGGANJUNZHIDUOTANG(LPS)GONGDUHOUDASHUIgADEFENMI,YIZHICUYANXINGXIBAOYINZIHEQUHUAYINZIDEBIAODA[45]。ZHUSHANGDEYANJIUBIAOMING,SILIANGTIANJIA4%DEMCFAsYIZHICHANGDAOHEGANZANGTollYANGSHOUTI4(TLR4)HEHEGANSUANJIEHEGUAJUYUSHOUTI(NOD)XINHAOTONGLU,JIANGDIZHONGLIUHUAISIYINZISHOUTIXIANGGUANYINZI6(TRAF6)、HEYINZINF-κBHESHOUTIHUZUODANBAIJIMEI2(RIPK2)DENGXIAYOUXIANGGUANJIYINDEmRNABIAODASHUIPING,SHUOMINGMCFAsJUYOULIANGHAODEKANGMIANYIYINGJIXIAOGUO,NENGGOUHUANJIELPSYOUDAODEDUANNAIZIZHUCHANGDAOHEGANZANGSUNSHANG[28]。

  XiaoDENG[46]TONGYANGFAXIAN,SILIANGTIANJIA4%MCTsJIANGDIZIZHUXUEQINGTNF-αHANLIANG,XIADIAOKONGCHANGHEHUICHANGTLR4HENODXINHAOTONGLUXIANGGUANJIYINBIAODA,KEYITUICEMCFAs/MCTsTONGGUOXIADIAOTLR4HENODXINHAOTONGLUHUANJIELPSYOUDAODECHANGDAOSUNSHANG。GAOWENYINGJIQINGKUANG,SILIANGTIANJIA0.3%DEMCFAsNENGTIGAOZIZHUXUEYEHEZUZHIZHONGREXIUKEDANBAI70DEmRNASHUIPING,HUANJIEREYINGJIDUIZIZHUZAOCHENGDEBULIANGFANYING[40]。CIWAI,MCFAsKEYIZUOWEIGUOYANGHUAWUMEITIZENGZHIJIJIHUOSHOUTIγ(PPARγ)DEPEITIJIHUOPPARXINHAOTONGLU,ERPPARXINHAOTONGLUZEYUCHENGZHIFENHUAYIJIMIANYIDIAOJIEYOUGUAN,YINCI,MCFAsDEMIANYIDIAOJIEGONGNENGKENENGYUPPARγDEHUOHUAYOUGUAN[47-48]。

幸运飞艇app   2.4MCFAsDUIZIZHUCHANGDAOWANZHENGXINGDEDIAOJIEXIAOCHANGNIANMOSHANGPISHIYINGYANGWUZHIJIANGJIEHEXISHOUDEZHUYAOBUWEI,XIAOCHANGRONGMAOHEYINWOYINGXIANGNIANMOGONGNENGBIAOMIANJI。RONGMAOJIANFUJINDESHANGPIXIBAOZUIWEICHENGSHUQIEYONGYOUZUIDADEXIAOHUAHEXISHOUNENGLI,YINCI,ZIZHUTIZHONGZENGJIAYURONGMAOGAODUMIQIEXIANGGUAN[49]。YANJIUFAXIAN,SILIANGTIANJIABUTONGSHUIPINGDEMCFAs(0.2%、0.4%HE0.6%)KETIGAODUANNAIZIZHUXIAOCHANGRONGMAOGAODU,CUJINYINGYANGWUZHIXIAOHUAXISHOU[27]。4%DEMCFAsZENGJIAXIAOCHANGRONGMAOGAODU、KONGCHANGZHETANGMEIHEMAIYATANGMEIYIJIHUICHANGJIANXINGLINSUANMEIDEHUOXING,GAISHANXIAOHUAXISHOUGONGNENG[28]。LPSGONGDUJIANGDIZIZHUCHANGDAORONGMAOGAODU,POHUAICHANGDAOJIEGOUWANZHENGXING,ERSILIANGTIANJIA0.175%MCTsKETIGAORONGMAOGAODU,ZENGJIAKONGCHANGHEHUICHANGBEIZHUANGXIBAOHEJIANGXIBAODESHULIANG,HUANJIELPSGONGDUDUIZIZHUCHANGDAOZAOCHENGDESUNSHANG,JINERCUJINDUANNAIZIZHUSHENGZHANG[34]。

幸运飞艇app   YINCI,MCFAsDUICHANGDAOXINGTAIJIEGOUWANZHENGXINGDEDIAOJIEJUYOUZHONGYAOZUOYONG。JINYIBUTANSUOJILIFAXIAN,TIANJIAMCFAsKESHANGDIAOIPEC-J2XIBAOClaudin-4JIYINDEBIAODA[38],TIANJIAMCTsKESHANGDIAOZIZHUCHANGDAOClaudin-1DANBAIBIAODA,TONGSHIXIADIAOJIHUOSUSHOUTIXIANGHUZUOYONGDANBAI(RIP-3)HEHUNHEPUXIJIMEIYUYANGDANBAI(MLKL)DEmRNASHUIPING,TUICEMCFAsDUICHANGDAOJIEGOUWANZHENGXINGDEWEICHIZUOYONGYURIP-3HEMLKLXINHAOTONGLUYOUGUAN[46]。

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幸运飞艇app   YINCI,RILIANGZHONGTIANJIA1.5%MCTsKETIGAOCHUANZANGHEIZHUDUANNAIZIZHUCHANGDAOZHONGYOUYIJUN(RUSUANGANJUNHESHUANGQIGANJUN)BILIBINGJIANGDIYOUHAIJUN(LIANQIUJUNHEDACHANGGANJUN)BILI,GAISHANCHANGDAOJUNQUNJIEGOU,JINERJIANGDIFUXIEZHISHU,TIGAOSHENGZHANGXINGNENG,KEZAIZIZHUSHANGTIDAI50mg/kgJINMEISU。CIWAI,MCFAsHEYOUJISUANLIANHESHIYONGTONGYANGKEZAIDUANNAIZIZHUSHANGTIDAIJINMEISU。SILIANGTIANJIA75mg/kgJINMEISUXIANZHUJIANGDIZIZHUDUANNAIHOU1~14dFUXIELV,DANLIANHETIANJIA0.2%YOUJISUANHE0.6%MCFAsKEZENGJIADUANNAIHOU1~28dPINGJUNRIZENGZHONGHESILIAOZHUANHUALV,TIGAOXUEQINGIgGHEIgADEHANLIANG,QIEYISHANGZHIBIAOYU75mg/kgJINMEISUZUCHAYIBUXIANZHU;LINGWAI,YOUJISUANHEMCFAsLIANHESHIYONGKETIGAOXUEQINGZONGKANGYANGHUANENGLI,JIANGDIBINGERQUANHANLIANG,TONGSHITIGAOCHANGDAOSHIMIZHONGHOUBIJUNMEN、BIANXINGJUNMEN、RUSUANGANJUNSHUHEFENGANJUNSHUDESHULIANG,SHUOMINGERZHELIANHESHIYONGKETONGGUODIAOJIEDUANNAIZIZHUDEWEISHENGWUQUN,GAISHANSHENGZHANGXINGNENG,JIANGDIFUXIELV,ZENGQIANGXUEQINGMIANYILI[42]。YINCI,MCFAsHEYOUJISUANZUHEKEZAIDUANNAIZIZHUSHANGZUOWEIQIANZAIDEKANGSHENGSUTIDAIPIN。

  4JIEYU

  ZONGTILAISHUO,MCFAsHUOMCTsKEYIZUOWEIDUANNAIZIZHUSILIAODELIANGHAOBUCHONGJI,SHIYIZHONGQIANZAIDESILIAOKANGSHENGSUTIDAIPIN。MCFAsKEYITONGGUOQIDUANTUJINGDEXISHOUHEYANGHUA、KANGJUNHEMIANYIDIAOJIEZUOYONGJINERWEICHICHANGSHANGPIJIEGOUWANZHENGXING,GAISHANZIZHUSHENGZHANGXINGNENG。ZHIDEZHUYIDESHI,MCFAsDUIZIZHUSHENGZHANGXINGNENGDEYANJIUJIEGUOBUWANQUANYIZHI,HAIXUJINYIBUTANTAOMCFAsZAIZIZHUYINGYONGSHIDEZUIJIATOUWEISHIJIAN、TIANJIAXINGSHI、TIANJIALIANG、SHENGCHANGONGYIJIRILIANGZHONGQITAYINGYANGSUDESHUIPINGDENGWENTI。MCFAsFEIDIANHENDI,RONGYIHUIFA,ZAISHIJISHENGCHANZHONGDEYINGYONGHAIXUKAIFAGENGJIAWENDINGDEJIXING。MCFAsZAIDONGWUSHENGCHANZHONGDEYINGYONGRENGBUGUANGFAN,JICHUYANJIUBUZU,XUYAOJINYIBUJIAQIANGMCFAsYUCHANGDAOFAYUJIMIANYIGONGNENGDEJILIYANJIUYIGENGHAODIZHIDAOYANGZHUSHENGCHAN。CIWAI,MCFAsZAIZHIFANGDAIXIEJITIGAODONGWUYINGJINENGLIDEXIANGGUANYANJIUFANGMIANYOUDAIJINYIBUSHENRU。

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